Sam Lord's Publications

grid lightbulb cell superres


20. WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility (HTML, PDF)
Fritz-Laylin, L. K.; Lord, S. J.; Mullins, R. D. J. Cell Biol. 2017, 216(6), 1673-1688.

19. Spatial Organization of EphA2 at the Cell-Cell Interface Modulates Trans-Endocytosis of EphrinA1 (HTML, PDF)
Greene, A. C.;* Lord, S. J.;* Tian, A.; Rhodes, C.; Kai, H.; Groves, J. T. Biophys. J. 2014, 106(10), 2196-2205. *equal contribution

18. Azido Push-Pull Fluorogens Photoactivate to Produce Bright Fluorescent Labels (HTML, PDF)
Lord, S. J.; Lee, H. D.; Samuel, R.; Weber, R.; Liu, N.; Conley, N. R.; Thompson, M. A.; Twieg, R. J.; Moerner, W. E. J. Phys. Chem. B 2010, 114(45), 14157-14167.

17. Superresolution Imaging of Targeted Proteins in Fixed and Living Cells Using Photoactivatable Organic Fluorophores (HTML, PDF) highlighted in Nature; evaluated by F1000
Lee, H. D.; Lord, S. J.; Iwanaga, S.; Zhan, K.; Xie, H.; Williams, J. C.; Wang, H.; Bowman, G. R.; Goley, E. D.; Shapiro, L.; Twieg, R. J.; Rao, J.; Moerner W. E. J. Am. Chem. Soc. 2010, 132(43), 15099-15101.

16. Review: Molecules and Methods for Super-Resolution Imaging (HTML, PDF)
Thompson, M. A.; Biteen, J. S.; Lord, S. J.; Conley, N. R.; Moerner, W. E. Methods Enzym. 2010, 475, 27-59.

15. Review: Single-Molecule Spectroscopy and Imaging of Biomolecules in Living Cells (HTML, PDF)
Lord, S. J.; Lee, H. D.; Moerner, W. E. Anal. Chem. 2010, 82(6), 2192-2203.

14. Single-Molecule Fluorophores as Environmental Nanoprobes (HTML, PDF)
Liu, N.; Lu, Z.; Ougaddoum, H.; Wang, H.; Weber, R.; Williams, J.; Yang, Z.; Twieg R.; Lord, S. J. Moroccan J. Cond. Matter 2009, 11(2), 90-98.

13. Photoactivatable DCDHF fluorophores for single-molecule imaging (HTML, PDF)
Lord, S. J.; Conley, N. R.; Lee, H. D.; Liu, N.; Samuel, R.; Twieg, R. J.; Moerner, W. E. Proc. SPIE 2009, 7190, 719013.

12. Three-Dimensional Single-Molecule Fluorescence Imaging Beyond the Diffraction Limit Using a Double-Helix Point Spread Function (HTML, PDF)
Pavani, S. R. P.; Thompson, M. A.; Biteen, J. S.; Lord, S. J.; Liu, N.; Twieg, R. J.; Piestun, R.; Moerner, W. E. Proc. Natl. Acad. Sci. U.S.A. 2009, 106(9), 2995-2999.

11. Bright, Red Single-Molecule Emitters: Synthesis and Properties of Environmentally Sensitive Dicyanomethylenedihydrofuran (DCDHF) Fluorophores with Bisaromatic Conjugation (HTML, PDF)
Lu, Z.; Liu, N.; Lord, S. J.; Willets, K. A.; Moerner, W. E.; Twieg, R. J. Chem. Mater. 2009, 21(5), 797-810.

10. Review: DCDHF Fluorophores for Single-Molecule Imaging in Cells (HTML, PDF)
Lord, S. J.; Conley, N. R.; Lee, H. D.; Nishimura, S. Y.; Pomerantz, A. K.; Willets, K. A.; Lu, Z.; Wang, H.; Liu, N.; Samuel, R.; Weber, R.; Semyonov, A.; He, M.; Twieg, R. J.; Moerner, W. E. ChemPhysChem 2009, 10(1), 55-65.

9. A Photoactivatable Push-Pull Fluorophore for Single-Molecule Imaging in Live Cells (HTML, PDF) highlighted in C&E News
Lord, S. J.; Conley, N. R.; Lee, H. D.; Samuel, R.; Liu, N.; Twieg, R. J.; Moerner, W. E. J. Am. Chem. Soc. 2008, 130(29), 9204-9205.

8. Chapter: Nanophotonics and Single Molecules (HTML, PDF)
Moerner, W. E.; Schuck, P. J.; Fromm, D. P.; Kinkhabwala, A.; Lord, S. J.; Nishimura, S. N.; Willets, K. A.; Sundaramurthy, A.; Kino, G.; He, M.; Lu, Z.; Twieg, R. J. Chapter in Single Molecules and Nanotechnology; R. Rigler and H. Vogel, Eds.; Springer Series in Biophysics, Vol. 12; Springer-Verlag: Berlin, 2008; pp 1-23.

7. Photophysical Properties of Acene DCDHF Fluorophores: Long-Wavelength Single-Molecule Emitters Designed for Cellular Imaging (HTML, PDF)
Lord, S. J.; Lu, Z.; Wang, H.; Willets, K. A.; Schuck, P. J; Lee, H. D.; Nishimura, S. Y.; Twieg, R. J.; Moerner, W. E. J. Phys. Chem. A 2007, 111(37), 8934-8941.

6. Modifications of DCDHF Single Molecule Fluorophores to Impart Water Solubility (HTML, PDF)
Wang, H.; Lu, Z.; Lord, S. J.; Moerner, W. E.; Twieg, R. J. Tetrahedron Lett. 2007, 48(19), 3471-3474.

5. The influence of tetrahydroquinoline rings in dicyanomethylenedihydrofuran (DCDHF) single-molecule fluorophores (HTML, PDF)
Wang, H; Lu, Z.; Lord, S. J.; Willets, K. A.; Bertke, J. A.; Bunge, S. D.; Moerner, W. E.; Twieg, R. J. Tetrahedron 2007, 63(1), 103-114.

4. A Long-Wavelength Analogue of PRODAN: Synthesis and Properties of Anthradan, a Fluorophore with a 2,6-Donor-Acceptor Anthracene Structure (HTML, PDF)
Lu, Z.; Lord, S. J.; Wang, H.; Moerner, W. E.; Twieg, R. J. J. Org. Chem. 2006, 71(26), 9651-9657.

3. Diffusion of Lipid-like Single-Molecule Fluorophores in the Cell Membrane (HTML, PDF)
Nishimura, S. Y.; Lord, S. J.; Klein, L. O.; Willets, K. A.; Lu, Z.; He, M.; Twieg, R. J.; Moerner, W. E. J. Phys. Chem. B 2006, 110(15), 8151-8157.

2. Synthesis, Properties, and Applications of Dicyanomethylenedihydrofuran (DCDHF) Single Molecule Fluorophores (HTML, PDF)
Twieg, R.; Wang, H.; Lu, Z. Kim, S. Y.; Lord, S.; Nishimura, S.; Schuck, P. J.; Willets, K. A.; Moerner, W. E. Nonlinear Optics, Quantum Optics 2005, 34, 241-246.

1. Tadpole conformation of gradient polymer brushes (HTML, PDF)
Lord, S. J.; Sheiko, S. S.; LaRue, I.; Lee, H. I.; Matyjaszewski, K. Macromolecules 2004, 37(11), 4235-4240.


Patents:

2. Fluorogenic Compounds Converted to Fluorophores by Photochemical or Chemical Means and Their Use in Biological Systems (HTML, PDF)
Twieg, R. J.; Moerner, W. E.; Lord, S. J.; Liu, N.; Samuel, R. US Patent 8,772,048. Filed March 1, 2012; issued July 8, 2014.

1. Fluorogenic Compounds Converted to Fluorophores by Photochemical or Chemical Means and Their Use in Biological Systems (HTML, PDF)
Twieg, R. J.; Moerner, W. E.; Lord, S. J.; Liu, N.; Samuel, R. US Patent 8,153,446. Filed May 13, 2009; issued April 10, 2012.


Dissertation: Fluorophores for Single-Molecule Imaging in Living Cells: Characterizing and Optimizing DCDHF Photophysics (HTML, PDF)
Lord, S. J. Ph.D. Dissertation, Stanford University, March 2010.


Preprints:

2. Three-dimensional actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes (HTML, PDF)
Fritz-Laylin, L. K.; Riel-Mehan, M.; Chen, B.-C.; Lord, S. J.; Goddard, T. D.; Ferrin, T. E.; Johnson, G.; Betzig, E.; Mullins, R. D. bioRxiv 2017.

1. Chytrid fungi construct actin-rich pseudopods, implicating actin regulators WASP and SCAR in an ancient mode of cell motility (HTML, PDF)
Fritz-Laylin, L. K.; Lord, S. J.; Mullins, R. D. bioRxiv 2016.